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muTarget
connect mutation status to gene expression changes in solid tumours
Start analysis by querying for:
Genotype
Target
GENOTYPE
Run using:
Single gene
Multiple genes (max 5)
Enter gene symbol(s) here:
Select somatic mutation type:
All somatic mutations
Coding mutations
Non-coding mutations
Disruptive mutations
SETTINGS
Select tumor type:
Bladder cancer (n=408)
Breast cancer - TCGA (n=979)
Breast cancer - Metabric (n=1862)
Cervix cancer (n=286)
Colon Adenocarcinoma (n=396)
Head and neck cancer (n=494)
Renal Clear Cell Carcinoma (n=332)
Renal Papillary Carcinoma (n=278)
Lower Grade Glioma (n=502)
Liver cancer (n=358)
Lung Adenocarcinoma (n=508)
Lung Squamous Carcinoma (n=488)
Ovarian cancer (n=272)
Prostate cancer (n=492)
Sarcoma (n=235)
Multiple Myeloma (n=738)
Melanoma (n=465)
Gastric cancer (n=372)
Thyroid cancer (n=485)
Uterine cancer (n=526)
All, except metabric (n=7876)
Mutation filter:
off
on
exclude
include
patients with mutation in
Set threshold:
Default threshold
Custom threshold
Exclude genes with a mean expression below 100:
No
Yes
P value cutoff:
0.05
0.01
0.001
0.0001
Expression fold change cutoff:
1.44
2.00
5.00
False Discovery Rate (FDR) cutoff:
No FDR filter
FDR < 5%
FDR < 10%
Mutation prevalence at least
1%
2%
3%
Generate table for:
All significant genes
Cancer hallmark genes only (
Menyhart et al., BBA, 2016
)
FDA approved drug target genes only
Show plot for:
top 5
top 10
top 20
top 30
Gene ontology:
off
on
Molecular function
Biological process
Results will be displayed on a new page.
