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muTarget
connect mutation status to gene expression changes in solid tumours
Running parameters
Selected gene(s):
TP53
Tumor type(s):
Breast cancer (TCGA)
Mutation type:
Coding mutations
Mutation filter:
Off
- exclude patients with mutation in:
-
- include patients with mutation in:
-
P value cutoff:
0.01
Fold change cutoff:
1.44
FDR cutoff:
No FDR filter
Exclude genes with a mean expression below 100:
Yes
Generate table for:
All significant genes
Show plot for:
top 5
Gene ontology:
Off
RESULTS
Breast cancer
Expression of
Mean mutant (n=305)
Mean wild (n=674)
FC (mutant/wild)
Direction
p-value
MLPH
3941.72
11449.82
2.94
down
3.62e-65
ANKRA2
298.72
525.13
1.75
down
2.15e-64
CENPA
385.8
141.59
2.72
up
2.44e-63
TBC1D9
5254.93
15823.77
3.03
down
6.11e-63
CBX2
1289.05
461.19
2.8
up
3.01e-61
THSD4
1634.29
5062.63
3.12
down
2.62e-60
CDC20
1986.13
748.34
2.65
up
3.27e-60
PSAT1
1083.35
192.08
5.64
up
1.17e-59
GATA3
7418.64
19961.58
2.7
down
6.94e-59
HHAT
374.68
791.07
2.13
down
1.61e-58
Download results table for all significant genes
Download plots as pdf